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SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
USERS' SCORE
Good
Based on 1 Review
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
Vitamin D3 shows antifungal promise
Antifungal activity of vitamin D against Candida albicans in vitro and in vivo.
Directly addresses yeast infection treatment
We explored the antifungal effects of vitamin D3 against yeast infections, focusing on Candida albicans, in a thorough study. Using a variety of methods, including a broth microdilution test and solid plate assays, we found that vitamin D3 significantly inhibits the growth of different Candida species in a way that was both broad and dose-dependent.
Additionally, vitamin D3 showed a strong antifungal effect during the crucial phases of biofilm formation—this is important because Candida can often form protective layers that make infections harder to treat. We investigated the mechanism behind this action and discovered that vitamin D3 affects several metabolic pathways within the yeast, suggesting that it operates through multiple targets.
In an experimental model of intra-abdominal candidiasis, we noted that vitamin D3 reduced fungal presence in key organs like the liver and kidneys. Furthermore, analysis revealed that treatment with vitamin D3 resulted in less inflammation, as indicated by decreased inflammatory cell presence and lower levels of specific cytokines in the blood. Overall, these findings propose vitamin D3 as a promising new treatment option for combating yeast infections, particularly in difficult-to-treat cases like intra-abdominal candidiasis.
Additionally, vitamin D3 showed a strong antifungal effect during the crucial phases of biofilm formation—this is important because Candida can often form protective layers that make infections harder to treat. We investigated the mechanism behind this action and discovered that vitamin D3 affects several metabolic pathways within the yeast, suggesting that it operates through multiple targets.
In an experimental model of intra-abdominal candidiasis, we noted that vitamin D3 reduced fungal presence in key organs like the liver and kidneys. Furthermore, analysis revealed that treatment with vitamin D3 resulted in less inflammation, as indicated by decreased inflammatory cell presence and lower levels of specific cytokines in the blood. Overall, these findings propose vitamin D3 as a promising new treatment option for combating yeast infections, particularly in difficult-to-treat cases like intra-abdominal candidiasis.
Read More
8
Vitamin D3 shifts immune response
1,25-dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses.
Significant immune modulation observed
We investigated the effects of vitamin D3, also known as 1,25-dihydroxyvitamin D3, on yeast infections, specifically looking at how it influences cytokine production in response to Candida albicans. In our study, we worked with peripheral blood mononuclear cells (PBMC) from healthy volunteers. When we stimulated these cells with C. albicans along with vitamin D3, we discovered that vitamin D3 caused a noticeable shift in cytokine responses.
Specifically, we observed that vitamin D3 reduced the production of pro-inflammatory cytokines such as IL-6, TNFα, IL-17, and IFNγ while increasing levels of the anti-inflammatory cytokine IL-10. This change points towards an overall anti-inflammatory profile, which could be beneficial in managing yeast infections.
Additionally, our findings revealed that vitamin D3 inhibited the expression of key receptors involved in the immune response—specifically TLR2, TLR4, Dectin-1, and the mannose receptor. Notably, we noticed a seasonal variation, as immune responses, particularly levels of IL-17 and IFNγ, were suppressed in the summer months when vitamin D levels were higher.
These findings underscore the potential of vitamin D3 in modifying immune responses to Candida albicans, highlighting its relevance during different seasons of the year.
Specifically, we observed that vitamin D3 reduced the production of pro-inflammatory cytokines such as IL-6, TNFα, IL-17, and IFNγ while increasing levels of the anti-inflammatory cytokine IL-10. This change points towards an overall anti-inflammatory profile, which could be beneficial in managing yeast infections.
Additionally, our findings revealed that vitamin D3 inhibited the expression of key receptors involved in the immune response—specifically TLR2, TLR4, Dectin-1, and the mannose receptor. Notably, we noticed a seasonal variation, as immune responses, particularly levels of IL-17 and IFNγ, were suppressed in the summer months when vitamin D levels were higher.
These findings underscore the potential of vitamin D3 in modifying immune responses to Candida albicans, highlighting its relevance during different seasons of the year.
Read More
8
Vitamin D3 shows antifungal promise
Virtual screening and drug repositioning as strategies for the discovery of new antifungal inhibitors of oxidosqualene cyclase.
Highlights vitamin D3 use in infections
We explored the potential of vitamin D3, particularly its active form calcitriol, in addressing yeast infections, specifically those caused by Candida albicans. The study focused on the enzyme oxidosqualene cyclase (OSC), which plays a crucial role in the lifecycle of these fungi.
Through a combination of virtual screening and molecular docking techniques, we pinpointed calcitriol along with several other existing drugs as potential inhibitors of CaOSC. This screening revealed promising interactions, including a key hydrogen bond with an essential residue of the enzyme.
To see how well calcitriol performed as an antifungal agent, we conducted in vitro tests against various strains of Candida. The results were encouraging, showing that calcitriol has antifungal activity against both C. albicans and C. tropicalis. This suggests that calcitriol could be a viable candidate for future treatments of yeast infections, particularly in immunocompromised individuals who are at higher risk.
Overall, our findings highlight the potential of repositioning calcitriol as a therapeutic option against yeast infections, paving the way for innovative antifungal strategies.
Through a combination of virtual screening and molecular docking techniques, we pinpointed calcitriol along with several other existing drugs as potential inhibitors of CaOSC. This screening revealed promising interactions, including a key hydrogen bond with an essential residue of the enzyme.
To see how well calcitriol performed as an antifungal agent, we conducted in vitro tests against various strains of Candida. The results were encouraging, showing that calcitriol has antifungal activity against both C. albicans and C. tropicalis. This suggests that calcitriol could be a viable candidate for future treatments of yeast infections, particularly in immunocompromised individuals who are at higher risk.
Overall, our findings highlight the potential of repositioning calcitriol as a therapeutic option against yeast infections, paving the way for innovative antifungal strategies.
Read More
Most Useful Reviews
9.5
Effective treatment
Excellent! I've been taking D3 for a year—15,000 in winter and 10,000 in summer. I haven't been ill during autumn and winter. My metabolism improved and I successfully conceived after eight years of trying. Now pregnant, I take 10,000. If I notice symptoms of a yeast infection, I increase to 20,000, and it rectifies the issue within a day. D3 strengthens mucous membranes, making them less prone to infections.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.3
9
Vitamin D3 shows antifungal promise
Antifungal activity of vitamin D against Candida albicans in vitro and in vivo.
Directly addresses yeast infection treatment
We explored the antifungal effects of vitamin D3 against yeast infections, focusing on Candida albicans, in a thorough study. Using a variety of methods, including a broth microdilution test and solid plate assays, we found that vitamin D3 significantly inhibits the growth of different Candida species in a way that was both broad and dose-dependent.
Additionally, vitamin D3 showed a strong antifungal effect during the crucial phases of biofilm formation—this is important because Candida can often form protective layers that make infections harder to treat. We investigated the mechanism behind this action and discovered that vitamin D3 affects several metabolic pathways within the yeast, suggesting that it operates through multiple targets.
In an experimental model of intra-abdominal candidiasis, we noted that vitamin D3 reduced fungal presence in key organs like the liver and kidneys. Furthermore, analysis revealed that treatment with vitamin D3 resulted in less inflammation, as indicated by decreased inflammatory cell presence and lower levels of specific cytokines in the blood. Overall, these findings propose vitamin D3 as a promising new treatment option for combating yeast infections, particularly in difficult-to-treat cases like intra-abdominal candidiasis.
Additionally, vitamin D3 showed a strong antifungal effect during the crucial phases of biofilm formation—this is important because Candida can often form protective layers that make infections harder to treat. We investigated the mechanism behind this action and discovered that vitamin D3 affects several metabolic pathways within the yeast, suggesting that it operates through multiple targets.
In an experimental model of intra-abdominal candidiasis, we noted that vitamin D3 reduced fungal presence in key organs like the liver and kidneys. Furthermore, analysis revealed that treatment with vitamin D3 resulted in less inflammation, as indicated by decreased inflammatory cell presence and lower levels of specific cytokines in the blood. Overall, these findings propose vitamin D3 as a promising new treatment option for combating yeast infections, particularly in difficult-to-treat cases like intra-abdominal candidiasis.
Read More
8
Vitamin D3 shows antifungal promise
Virtual screening and drug repositioning as strategies for the discovery of new antifungal inhibitors of oxidosqualene cyclase.
Highlights vitamin D3 use in infections
We explored the potential of vitamin D3, particularly its active form calcitriol, in addressing yeast infections, specifically those caused by Candida albicans. The study focused on the enzyme oxidosqualene cyclase (OSC), which plays a crucial role in the lifecycle of these fungi.
Through a combination of virtual screening and molecular docking techniques, we pinpointed calcitriol along with several other existing drugs as potential inhibitors of CaOSC. This screening revealed promising interactions, including a key hydrogen bond with an essential residue of the enzyme.
To see how well calcitriol performed as an antifungal agent, we conducted in vitro tests against various strains of Candida. The results were encouraging, showing that calcitriol has antifungal activity against both C. albicans and C. tropicalis. This suggests that calcitriol could be a viable candidate for future treatments of yeast infections, particularly in immunocompromised individuals who are at higher risk.
Overall, our findings highlight the potential of repositioning calcitriol as a therapeutic option against yeast infections, paving the way for innovative antifungal strategies.
Through a combination of virtual screening and molecular docking techniques, we pinpointed calcitriol along with several other existing drugs as potential inhibitors of CaOSC. This screening revealed promising interactions, including a key hydrogen bond with an essential residue of the enzyme.
To see how well calcitriol performed as an antifungal agent, we conducted in vitro tests against various strains of Candida. The results were encouraging, showing that calcitriol has antifungal activity against both C. albicans and C. tropicalis. This suggests that calcitriol could be a viable candidate for future treatments of yeast infections, particularly in immunocompromised individuals who are at higher risk.
Overall, our findings highlight the potential of repositioning calcitriol as a therapeutic option against yeast infections, paving the way for innovative antifungal strategies.
Read More
8
Vitamin D3 shifts immune response
1,25-dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses.
Significant immune modulation observed
We investigated the effects of vitamin D3, also known as 1,25-dihydroxyvitamin D3, on yeast infections, specifically looking at how it influences cytokine production in response to Candida albicans. In our study, we worked with peripheral blood mononuclear cells (PBMC) from healthy volunteers. When we stimulated these cells with C. albicans along with vitamin D3, we discovered that vitamin D3 caused a noticeable shift in cytokine responses.
Specifically, we observed that vitamin D3 reduced the production of pro-inflammatory cytokines such as IL-6, TNFα, IL-17, and IFNγ while increasing levels of the anti-inflammatory cytokine IL-10. This change points towards an overall anti-inflammatory profile, which could be beneficial in managing yeast infections.
Additionally, our findings revealed that vitamin D3 inhibited the expression of key receptors involved in the immune response—specifically TLR2, TLR4, Dectin-1, and the mannose receptor. Notably, we noticed a seasonal variation, as immune responses, particularly levels of IL-17 and IFNγ, were suppressed in the summer months when vitamin D levels were higher.
These findings underscore the potential of vitamin D3 in modifying immune responses to Candida albicans, highlighting its relevance during different seasons of the year.
Specifically, we observed that vitamin D3 reduced the production of pro-inflammatory cytokines such as IL-6, TNFα, IL-17, and IFNγ while increasing levels of the anti-inflammatory cytokine IL-10. This change points towards an overall anti-inflammatory profile, which could be beneficial in managing yeast infections.
Additionally, our findings revealed that vitamin D3 inhibited the expression of key receptors involved in the immune response—specifically TLR2, TLR4, Dectin-1, and the mannose receptor. Notably, we noticed a seasonal variation, as immune responses, particularly levels of IL-17 and IFNγ, were suppressed in the summer months when vitamin D levels were higher.
These findings underscore the potential of vitamin D3 in modifying immune responses to Candida albicans, highlighting its relevance during different seasons of the year.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.6
9.5
Effective treatment
Excellent! I've been taking D3 for a year—15,000 in winter and 10,000 in summer. I haven't been ill during autumn and winter. My metabolism improved and I successfully conceived after eight years of trying. Now pregnant, I take 10,000. If I notice symptoms of a yeast infection, I increase to 20,000, and it rectifies the issue within a day. D3 strengthens mucous membranes, making them less prone to infections.
Read More
